Paralysis is loss of muscle function for one or more muscles. Paralysis accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage as well as motor. About 1 in 50 people in the U.S. have been diagnosed with some form of paralysis, transient or permanent
Paralysis is most often caused by damage in the nervous system, especially the spinal cord. Other major causes are stroke, trauma with nerve injury, poliomyelitis, cerebral palsy, peripheral neuropathy, Parkinson's disease, ALS, botulism, spina bifida, multiple sclerosis, and Guillain–Barré syndrome. Temporary paralysis occurs during REM sleep, and dysregulation of this system can lead to episodes of waking paralysis. Drugs that interfere with nerve function, such as curare, can also cause paralysis.